Bures J, Horácek J, Davidová M, Král B, Pidrman V
interní klinika FN a LF UK, Hradec Králové.
Cas Lek Cesk. 1995 Apr 19;134(8):240-2.
Crohn's disease (CD) is associated with smoking and ulcerative colitis with non-smokers. The aim of study was to compare resting energy status of smokers is worse when compared with non-smokers. The aim of the study was to compare resting energy expenditure (REE) in smokers and non-smokers with CD.
REE was measured in the morning in 18 fasting patients with CD (11 non-smokers, 7 smokers) using a metabolic cart (Deltatrac Datex) in a canopy system. In smokers REE was measured before and 30 minutes after having smoked one cigarette, in non-smokers before and 30 minutes after light physical activity. The results were expressed in per cent of the expected values calculated from Harris-Benedict formula (%HB). In CD REE was significantly higher in smokers when compared with non-smokers (mean +/- S.E.M.: 113.3 +/- 12.7 vs 103.1 +/- 10.2; p < 0.03; t-test). The increase of the second measurement was not significant both in smokers (115.4 +/- 9.4) and non-smokers (105.4 +/- 10.3). In 15 CD patients substrate utilization was also estimated from indirect calorimetry and urea production. There was a higher rate of glycides (mean +/- S.E.M.: 185.9 +/- 81.9 gm/min) and a lower rate of protein oxidation (22.7 +/- 15.5) in smokers when compared with non-smokers (glycides: 141.6 +/- 78.0, NS; proteins: 41.8 +/- 36.7, NS). There was no significant difference between smokers and non-smokers with CD in lipids oxidation (33.7 +/- 19.5 vs 32.9 +/- 22.3).
A significantly higher REE was found in smokers with CD when compared with non-smokers with CD. Differences in substrate utilization were not significant. Our results support a recommendation for CD patients to be non-smokers.
克罗恩病（CD）与吸烟有关，而溃疡性结肠炎与非吸烟者有关。本研究的目的是比较吸烟者与非吸烟者的静息能量状态，结果发现吸烟者的静息能量状态更差。本研究的目的是比较患有CD的吸烟者和非吸烟者的静息能量消耗（REE）。
使用代谢车（Datex Deltatrac）在密闭系统中对18例空腹的CD患者（11例非吸烟者，7例吸烟者）在早晨测量REE。对吸烟者，在吸一支烟之前和之后30分钟测量REE；对非吸烟者，在轻度体力活动之前和之后30分钟测量REE。结果以根据哈里斯- Benedict公式计算的预期值的百分比（%HB）表示。在CD患者中，吸烟者的REE显著高于非吸烟者（平均值±标准误：113.3±12.7对103.1±10.2；p<0.03；t检验）。第二次测量的增加在吸烟者（115.4±9.4）和非吸烟者（105.4±10.3）中均不显著。对15例CD患者，还通过间接测热法和尿素生成来估计底物利用情况。与非吸烟者相比，吸烟者的糖类利用率较高（平均值±标准误：185.9±81.9克/分钟），蛋白质氧化率较低（22.7±15.5）（糖类：141.6±78.0，无显著性差异；蛋白质：41.8±36.7，无显著性差异）。CD吸烟者和非吸烟者在脂质氧化方面无显著差异（33.7±19.5对32.9±22.3）。
与患有CD的非吸烟者相比，患有CD的吸烟者的REE显著更高。底物利用方面的差异不显著。我们的结果支持建议CD患者戒烟。
