Fujisawa S
Faculty of Dentistry, Tokyo Medical and Dental University, Japan.
Dent Mater J. 1994 Dec;13(2):251-5. doi: 10.4012/dmj.13.251.
2, 2-Bis [4- (2-hydroxy-3-methacryloyloxypropoxy) phenyl] propane (bis-GMA) is widely used in dentistry as a monomer of composite resin system and their bonding agents. Since bis-GMA is not purified, its isomers and some chemicals such as residual initiator remain in the commercial product. Bis-GMA and iso-bis-GMA were separated from bis-GMA monomer by HPLC. NMR spectra of both monomers were recorded, and their all signals in 1H and 13C-NMR spectra were assigned using DEPT and COSY experiments.
2,2-双[4-(2-羟基-3-甲基丙烯酰氧基丙氧基)苯基]丙烷（双-GMA）作为复合树脂体系及其粘结剂的单体，在牙科领域广泛应用。由于双-GMA未经过提纯，其异构体以及一些化学物质（如残留引发剂）仍存在于商业产品中。通过高效液相色谱法（HPLC）从双-GMA单体中分离出双-GMA和异双-GMA。记录了两种单体的核磁共振光谱，并利用无畸变极化转移增强法（DEPT）和化学位移相关谱（COSY）实验对它们在氢核磁共振（1H-NMR）谱和碳核磁共振（13C-NMR）谱中的所有信号进行了归属。
