Bonfiglio G, Stefani S, Nicoletti G
Istituto di Microbiologia Medica, Università di Catania, Italy.
Chemotherapy. 1995 Mar-Apr;41(2):121-4. doi: 10.1159/000239332.
Xanthomonas maltophilia produces two inducible beta-lactamases, L-1 and L-2, and resists the antimicrobial activity of beta-lactam antibiotics including carbapenems. L-1 has carbapenemase activity and L-2 is a cephalosporinase. It has been suggested that these beta-lactamases share regulatory components. We isolated a recent clinical X. maltophilia strain susceptible to carbapenems and resistant to almost all the other beta-lactam antibiotics tested. beta-Lactamase induction with cefotaxime showed that the clinical isolate had low-level expression of L-1 beta-lactamase but remained inducible for L-2 enzyme. The possible relationship of this enzyme to carbapenem sensitivity is considered.
嗜麦芽窄食单胞菌产生两种诱导型β-内酰胺酶，L-1和L-2，并对包括碳青霉烯类在内的β-内酰胺抗生素的抗菌活性具有抗性。L-1具有碳青霉烯酶活性，L-2是一种头孢菌素酶。有人提出这些β-内酰胺酶共享调控成分。我们分离出了一株近期临床的嗜麦芽窄食单胞菌菌株，该菌株对碳青霉烯类敏感，但对几乎所有其他测试的β-内酰胺抗生素耐药。用头孢噻肟诱导β-内酰胺酶表明，该临床分离株L-1β-内酰胺酶表达水平较低，但L-2酶仍可诱导。考虑了这种酶与碳青霉烯敏感性之间的可能关系。
