Eistert B, Kirchmaier C, Risse M, Glanz H
Klinik für Hals-Nasen-Ohrenheilkunde, Universität Giessen.
HNO. 1995 Mar;43(3):177-81.
Tonsillectomies are the most frequently performed ENT surgical procedures and are potentially beset with a number of possible complications. Post-operative secondary hemorrhage still remains the most frequent complication despite improvements in surgical techniques and preoperative diagnostic evaluations. Besides unsuitable operative techniques, disturbances of circulation and wound infections, disturbances of hemostasis may play an important part. The objective of this paper was to examine the relative frequency of platelet functional disorders as a possible cause for secondary hemorrhage after tonsillectomies. In the past, most of these have been related to medication use. Eighty-nine patients were studied and historically showed no predisposition increased hemorrhage per se or in their families or gave reasons for other factors favoring secondary hemorrhage. The diminution or lack of collagen or ADP-induced agglutination served as an indication for a platelet functional disorder. Ten percent of the 89 patients experienced secondary hemorrhage, with platelet functional disorders proved in 40% of these patients. Because of these results a correlation was attempted between secondary hemorrhage and abnormal deficits of collagen and ADP-induced agglutinations in platelet functional tests, but this was not found. Necessary preoperative studies was attempted screening for hemostasis as well as medico-legal aspects connected with the prescription of medicines inhibiting platelet agglutination, especially use of acetylsalicylic acid before tonsillectomies, are discussed.
扁桃体切除术是耳鼻喉科最常进行的外科手术,可能会面临许多潜在并发症。尽管手术技术和术前诊断评估有所改进,但术后继发性出血仍然是最常见的并发症。除了不合适的手术技术、循环系统紊乱和伤口感染外,止血障碍可能起重要作用。本文的目的是研究血小板功能障碍作为扁桃体切除术后继发性出血可能原因的相对频率。过去,其中大多数与药物使用有关。对89名患者进行了研究,从病史来看,他们本身或其家族均无出血倾向增加的情况,也没有其他有利于继发性出血的因素。胶原或二磷酸腺苷(ADP)诱导的凝集减少或缺乏被用作血小板功能障碍的指标。89名患者中有10%发生了继发性出血,其中40%的患者被证实存在血小板功能障碍。基于这些结果,试图探寻继发性出血与血小板功能试验中胶原和ADP诱导凝集异常缺乏之间的关联,但未发现这种关联。本文还尝试讨论了术前必要的研究,即针对止血进行筛查,以及与抑制血小板凝集药物处方相关的法医学问题,特别是扁桃体切除术前使用乙酰水杨酸的情况。