Elhanan K, Siplovich L, Raz R
Department of Pediatrics A, Central Emek Hospital, Afula, Israel.
J Antimicrob Chemother. 1995 Feb;35(2):327-32. doi: 10.1093/jac/35.2.327.
Fifty children aged 3 months--16 y with Gram-negative bacterial infections, were evaluated in this open randomized study; 26 received gentamicin 4.5 mg/kg/day, once daily, and 24 received the same daily dosage, in three divided doses. The groups had similar demographic and clinical characteristics. Serum trough gentamicin concentrations were significantly lower in the od group than in the tds group, while peak concentration were significantly higher in the od group. Clinical cure was obtained in 23 of the 26 (88.8%) children who received gentamicin once daily, and in 22/24 (91%) children treated thrice daily. Microbiological cure was obtained in 10/10 (100%) and 12/13 (92%) of the evaluated cases. Nephrotoxicity was not observed but ototoxicity occurred in two children in each group. These results, although obtained from a small number of patients, showed a similar outcome in children receiving gentamicin 4.5 mg/kg/day whether administered once or thrice daily.
在这项开放性随机研究中，对50名年龄在3个月至16岁之间患有革兰氏阴性菌感染的儿童进行了评估；26名儿童接受庆大霉素4.5mg/kg/天，每日一次，24名儿童接受相同的每日剂量，分三次给药。两组儿童的人口统计学和临床特征相似。每日一次给药组的血清庆大霉素谷浓度显著低于每日三次给药组，而每日一次给药组的峰浓度显著更高。每日接受一次庆大霉素治疗的26名儿童中有23名（88.8%）临床治愈，每日接受三次治疗的24名儿童中有22名（91%）临床治愈。评估病例中，10/10（100%）和12/13（92%）实现了微生物学治愈。未观察到肾毒性，但每组均有两名儿童出现耳毒性。这些结果虽然来自少数患者，但表明每日接受4.5mg/kg庆大霉素治疗的儿童，无论每日给药一次还是三次，疗效相似。
