MacGowan A P, Bowker K E, Bedford K A, Holt H A, Reeves D S, Hedges A
Department of Medical Microbiology, Southmead Health Services NHS Trust, Westbury-on Trym, Bristol, UK.
J Antimicrob Chemother. 1995 Feb;35(2):333-7. doi: 10.1093/jac/35.2.333.
The inhibitory and bactericidal activities of meropenem and imipenem were compared using Acinetobacter spp. and Enterobacteriaceae resistant to second generation cephalosporins. The inhibitory activity of both agents was similar for Acinetobacter spp. but meropenem was more active against the Enterobacteriaceae. Bactericidal activities were compared employing time-kill curves which indicated meropenem was more bactericidal than imipenem against Enterobacteriaceae at pharmacologically achievable concentrations while imipenem was more bactericidal than meropenem against Acinetobacter spp.
使用对第二代头孢菌素耐药的不动杆菌属和肠杆菌科细菌比较了美罗培南和亚胺培南的抑菌和杀菌活性。两种药物对不动杆菌属的抑菌活性相似，但美罗培南对肠杆菌科细菌的活性更强。采用时间杀菌曲线比较杀菌活性，结果表明在药理学可达到的浓度下，美罗培南对肠杆菌科细菌的杀菌作用比亚胺培南更强，而亚胺培南对不动杆菌属的杀菌作用比美罗培南更强。
