合成阿克罗菲林和阿克罗菲定的抗过敏活性。

The antiallergic activities of synthetic acrophylline and acrophyllidine.

作者信息

Huang A C, Lin T P, Kuo S C, Wang J P

机构信息

Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan.

出版信息

J Nat Prod. 1995 Jan;58(1):117-20. doi: 10.1021/np50115a016.

DOI:10.1021/np50115a016

PMID:7760067

Abstract

The antiallergic activities of synthetic acrophylline [1] and acrophyllidine [2] have been demonstrated. Both compounds 1 and 2 at 30 mumol/kg reduced the plasma leakage in mouse ear in a passive cutaneous anaphylactic (PCA) reaction. In addition, compound 1 suppressed mast cell degranulation in a dose-dependent manner, while compound 2 at 100 microM produced no significant inhibition of the release of preformed inflammatory mediators. These results suggest that the antiallergic effect of compound 1 probably occurs through the suppression of mast cell degranulation, and that of compound 2 by protection of the vasculature against challenge by mediators of inflammation.

摘要

已证实合成的acroophylline[1]和acroophyllidine[2]具有抗过敏活性。化合物1和2在30 μmol/kg时均可减少小鼠耳部被动皮肤过敏反应（PCA）中的血浆渗漏。此外，化合物1以剂量依赖的方式抑制肥大细胞脱颗粒，而100 μM的化合物2对预先形成的炎症介质的释放没有显著抑制作用。这些结果表明，化合物1的抗过敏作用可能是通过抑制肥大细胞脱颗粒实现的，而化合物2的抗过敏作用则是通过保护血管系统免受炎症介质的攻击来实现的。