Meuli M, Lorenz H P, Hedrick M H, Sullivan K M, Harrison M R, Adzick N S
Fetal Treatment Center, University of California, San Francisco 94143, USA.
J Pediatr Surg. 1995 Mar;30(3):392-5. doi: 10.1016/0022-3468(95)90039-x.
The aim of this study was to determine whether the fetal alimentary tract shares the unique scarless healing properties of fetal skin. Full-thickness incisional gastric wounds were created and sutured closed in fetal lambs at 60, 75, and 120 days' gestation (full term, 145 days), and in adult control sheep. At the time of harvest, 14 days postwounding, dense fibrous adhesions were found intraperitoneally in all fetal and adult animals. Histologically, all fetal and adult gastric wounds healed with pronounced scar formation. In contrast to the adult wound, there was no significant inflammatory response in the fetal wounds. Because scar formed in the absence of inflammation in fetal gastric wounds, there is no obvious relation between scarring and the inflammatory response at this location. This study shows that not all fetal tissues exhibit scarless repair properties.
本研究的目的是确定胎儿消化道是否具有胎儿皮肤独特的无瘢痕愈合特性。在妊娠60天、75天和120天（足月为145天）的胎羊以及成年对照羊身上制作全层切开的胃伤口并缝合关闭。在受伤后14天收获时，在所有胎羊和成年羊的腹腔内均发现了致密的纤维粘连。组织学上，所有胎羊和成年羊的胃伤口愈合时均有明显的瘢痕形成。与成年伤口不同，胎儿伤口没有明显的炎症反应。由于胎儿胃伤口在无炎症的情况下形成瘢痕，因此该部位的瘢痕形成与炎症反应之间没有明显关系。本研究表明，并非所有胎儿组织都具有无瘢痕修复特性。
