Kline I K, Thomas P A
Ann Thorac Surg. 1976 Jun;21(6):532-5. doi: 10.1016/s0003-4975(10)63924-0.
Lymphatic obstruction has not been emphasized as a feature of lung allograft rejection. However, accumulation of fluid and cellular infiltrate, aggravated by lymph stasis, results in impaired lung function. In this study, lung specimens were recovered at varying times up to 133 days after either reimplantation (7 dogs) or allografting (29 dogs). Azathioprine and prednisone were administered to 17 allograft recipients. The presence of abnormally dilated perivascular, peribronchiolar, and subpleural lymphatic channels was a consistent histological finding, most striking in specimens recovered from untreated allograft recipient dogs. Attenuated lymphatic alterations were noted in immunosuppressed allograft recipients. In these animals the pulmonary lymphatics seemed to be ineffectual in clearing the allograft of the accumulating cellular infiltrates and fluid during rejection.
淋巴阻塞尚未被视为肺移植排斥反应的一个特征。然而，淋巴淤滞加重了液体和细胞浸润的积聚，导致肺功能受损。在本研究中，在再植入（7只犬）或同种异体移植（29只犬）后长达133天的不同时间点采集肺标本。17只同种异体移植受体接受了硫唑嘌呤和泼尼松治疗。血管周围、细支气管周围和胸膜下淋巴管异常扩张是一致的组织学发现，在未经治疗的同种异体移植受体犬的标本中最为明显。在免疫抑制的同种异体移植受体中观察到淋巴管改变减轻。在这些动物中，肺淋巴管在清除排斥反应期间积聚的细胞浸润物和液体的同种异体移植方面似乎无效。
