Sabri O, Hellwig D, Kaiser H J, Doherty C, Schneider R, Mull M, Willmes von Hinckeldey K W, Büll U, Thron A, Ringelstein E B
Klinik für Nuklearmedizin, RWTH Aachen, FRG.
Nuklearmedizin. 1995 Apr;34(2):50-6.
51 patients with cerebral microangiopathy were studied with MRI, 18FDG-PET, and 99mTc-HMPAO-SPECT. Exact morphological correlation of MRI-findings to functional data from PET and SPECT was obtained by a special head holder system applied to the patient's head. Patients with less than four lacunar infarctions (LI) and without or only slight deep white matter lesions (DWML) in MRI showed no significantly changed parameters (rMRGlu, rCBF) compared to patients with four or more LI and severe DWML. Patients with medium to severe outer and inner brain atrophy showed significantly lower rMRGlu and rCBF values in both cortex and white matter than patients with no to only slight atrophy. Thus, in patients with cerebral microangiopathy only atrophy and not the presence of LI and DWML is associated with a significant reduction of rCBF and rMRGlu.
对51例脑微血管病患者进行了磁共振成像（MRI）、18氟脱氧葡萄糖正电子发射断层显像（18FDG-PET）和99锝-六甲基丙烯胺肟单光子发射计算机断层显像（99mTc-HMPAO-SPECT）检查。通过应用于患者头部的特殊头架系统，获得了MRI检查结果与PET和SPECT功能数据的精确形态学相关性。与有4个或更多腔隙性脑梗死（LI）且有严重深部白质病变（DWML）的患者相比，MRI显示LI少于4个且无或仅有轻微DWML的患者，其参数（相对脑葡萄糖代谢率[rMRGlu]、相对脑血流量[rCBF]）无显著变化。与无萎缩或仅有轻微萎缩的患者相比，有中度至重度脑内外萎缩的患者在皮质和白质中的rMRGlu和rCBF值均显著降低。因此，在脑微血管病患者中，仅萎缩而非LI和DWML的存在与rCBF和rMRGlu的显著降低相关。
