Bathmann J, Brugger W, Ullrich C, Mertelsmann R, Moser E
Radiologischen Universitätsklinik, Abteilung Nuklearmedizin, Klinikums der Albert-Ludwigs-Universität, Freiburg/Br., FRG.
Nuklearmedizin. 1995 Apr;34(2):66-70.
In 26 patients with plasmocytoma and 4 patients with benign monoclonal gammopathy bone marrow scintigraphy using 99mTc-labelled monoclonal antigranulocyte-antibodies was performed. Focal marrow defects were found in 18/26 patients with plasmocytoma but in none with benign monoclonal gammopathy. The results in plasmocytoma patients correlated well with the clinical staging system of Durie and Salmon. Quantification showed a suppressed bone marrow uptake ratio in 8/26 patients. A marked bone marrow expansion was present in only 2/26 patients. Bone marrow scintigraphy seems to be a valuable diagnostic tool in patients with plasmocytoma, especially as it is able to visualize the degree of bone marrow infiltration in a single protocol and so allows to follow up patients in a simple noninvasive manner.
对26例浆细胞瘤患者和4例良性单克隆丙种球蛋白病患者进行了使用99mTc标记的单克隆抗粒细胞抗体的骨髓闪烁显像。在26例浆细胞瘤患者中有18例发现局灶性骨髓缺损，但良性单克隆丙种球蛋白病患者均未发现。浆细胞瘤患者的结果与Durie和Salmon临床分期系统相关性良好。定量分析显示26例患者中有8例骨髓摄取率降低。26例患者中仅2例存在明显的骨髓扩张。骨髓闪烁显像似乎是浆细胞瘤患者的一种有价值的诊断工具，特别是因为它能够在单一检查中显示骨髓浸润程度，从而可以以简单的非侵入性方式对患者进行随访。
