Mutayoba B M, Eckersall P D, Cestnik V, Jeffcoate I A, Gray C E, Holmes P H
Department of Veterinary Clinical Biochemistry, University of Glasgow Veterinary School.
Res Vet Sci. 1995 Mar;58(2):174-9. doi: 10.1016/0034-5288(95)90073-x.
The effect of trypanosomiasis on adrenal function was studied in 10 pubertal Scottish blackface rams infected with Trypanosoma congolense and nine uninfected controls. Plasma cortisol concentration was measured by radioimmunoassay in samples obtained twice a week for three weeks before infection and three times a week for 79 days after infection. There was a significant (P < 0.001) increase in cortisol concentration in all the infected rams after the onset of parasitaemia nine to 16 days after infection. This was followed by a transient non-significant decrease in cortisol levels between 19 and 41 days and a variable and parasitaemia-dependent increase in cortisol levels between 44 and 79 days after infection. Marked hypertrophy of the zona fasciculata-reticularis, infiltration of mononuclear cells into the cortical and medullary zones, hyperaemia and focal coagulative necrosis were evident in the adrenal glands of infected rams killed at the end of the study. Trypanosome infection induced a low grade persistent pyrexia, marked anaemia, reduced growth rates and general loss of body condition. These results demonstrate that T congolense infection in sheep causes marked pathological changes in the adrenal cortex and changes in the secretion of cortisol.
研究了锥虫病对10只感染刚果锥虫的青春期苏格兰黑脸公羊和9只未感染的对照公羊肾上腺功能的影响。通过放射免疫分析法测定血浆皮质醇浓度，在感染前3周每周采集两次样本，感染后79天每周采集三次样本。感染后9至16天出现寄生虫血症后，所有感染公羊的皮质醇浓度均显著升高（P < 0.001）。随后，在感染后19至41天皮质醇水平出现短暂的非显著下降，在感染后44至79天皮质醇水平出现与寄生虫血症相关的可变升高。在研究结束时处死的感染公羊的肾上腺中，束状带-网状带明显肥大，单核细胞浸润到皮质和髓质区，充血和局灶性凝固性坏死明显。锥虫感染导致轻度持续性发热、明显贫血、生长率降低和身体状况普遍下降。这些结果表明，绵羊感染刚果锥虫会导致肾上腺皮质出现明显的病理变化以及皮质醇分泌改变。
