Mills P J, Dimsdale J E, Coy T V, Ancoli-Israel S, Clausen J L, Nelesen R A
Department of Psychiatry, University of California, San Diego, La Jolla 92103-0804, USA.
Sleep. 1995 Jan;18(1):39-42. doi: 10.1093/sleep/18.1.39.
This study examined the relationship between sleep apnea and beta 2-adrenergic receptor characteristics. Using standard polysomnography, individuals were classified as either apneic (n = 15) or mild to nonapneic (n = 15) according to their respiratory disturbance index (RDI). Subjects were similar in terms of sodium excretion and blood pressure. Apneic subjects showed a decrease in beta 2-adrenergic receptor sensitivity (p = 0.01) [as determined by isoproterenol-stimulated cyclic adenosine 5'-monophosphate (AMP) production in lymphocytes] and an increased binding affinity to the beta receptor antagonist [125I]iodopindolol (p < 0.001). beta receptor density was also diminished in apneics, but not significantly (p = 0.08). Forskolin-stimulated cyclic AMP was not significantly different between the groups, indicating a similarity in postreceptor Gs-adenylate cyclase activation. Across all subjects, RDI was negatively correlated with beta receptor sensitivity (r = -0.35, p = 0.05) and Kd (r = -0.54, p < 0.01) and positively correlated with systolic blood pressure (r = 0.37, p < 0.05). The findings indicate that sleep apnea is associated with a diminished beta 2-adrenergic receptor function but no change in postreceptor components and suggest a mechanism for the high comorbidity between sleep apnea and hypertension.
本研究调查了睡眠呼吸暂停与β2 - 肾上腺素能受体特征之间的关系。使用标准多导睡眠监测，根据呼吸紊乱指数（RDI）将个体分为呼吸暂停组（n = 15）或轻度至无呼吸暂停组（n = 15）。受试者在钠排泄和血压方面相似。呼吸暂停组受试者的β2 - 肾上腺素能受体敏感性降低（p = 0.01）[通过淋巴细胞中异丙肾上腺素刺激的环磷酸腺苷（AMP）生成来确定]，并且与β受体拮抗剂[125I]碘吲哚洛尔的结合亲和力增加（p < 0.001）。呼吸暂停组的β受体密度也降低，但无统计学意义（p = 0.08）。两组间福斯高林刺激的环磷酸腺苷无显著差异，表明受体后Gs - 腺苷酸环化酶激活相似。在所有受试者中，RDI与β受体敏感性（r = -0.35，p = 0.05）和解离常数（r = -0.54，p < 0.01）呈负相关，与收缩压呈正相关（r = 0.37，p < 0.05）。研究结果表明，睡眠呼吸暂停与β2 - 肾上腺素能受体功能减退有关，但受体后成分无变化，并提示了睡眠呼吸暂停与高血压之间高共病率的一种机制。
