Beck T, Goller H J, Wree A
Institut für Anatomie, Universität Rostock, Germany.
Stroke. 1995 Jun;26(6):1107-13. doi: 10.1161/01.str.26.6.1107.
The present investigation aimed to quantify functional activity in rat brains after long-term recovery from transient forebrain ischemia.
With the use of the [14C]2-deoxyglucose method, local cerebral glucose utilization was measured in 62 cortical and subcortical brain regions in postischemic rat brains. Transient forebrain ischemia of 10 minutes' duration was induced by clamping the common carotid arteries and simultaneously lowering blood pressure to 40 mm Hg. Rats survived the insults for 1 week, 2 weeks, 3 weeks, or 3 months.
Reductions predominated in the majority of gray matter structures at all time points investigated (P < .05). Except for a few areas, recoveries of local cerebral glucose utilization to preischemic levels did not occur.
The data illustrate that widespread alterations of functional activity prevail in postischemic brains beyond the selectively vulnerable regions. The present functional data are in line with previous stereological results of reduced fresh volumes in the majority of postischemic brain structures. The data suggest that chronic alterations of ischemic brains are not confined to the selectively vulnerable regions.
本研究旨在量化大鼠短暂性前脑缺血长期恢复后的脑功能活动。
采用[14C]2-脱氧葡萄糖法，测量缺血后大鼠脑内62个皮质和皮质下脑区的局部脑葡萄糖利用情况。通过夹闭双侧颈总动脉并同时将血压降至40 mmHg诱导持续10分钟的短暂性前脑缺血。大鼠在损伤后存活1周、2周、3周或3个月。
在所有研究时间点，大多数灰质结构的葡萄糖利用减少占主导（P <.05）。除少数区域外，局部脑葡萄糖利用未恢复到缺血前水平。
数据表明，缺血后脑内功能活动的广泛改变在选择性易损区域之外普遍存在。目前的功能数据与先前大多数缺血后脑结构新鲜体积减少的体视学结果一致。数据表明，缺血性脑的慢性改变并不局限于选择性易损区域。
