Kozuka M, Kobayashi K, Iwata N
New Lead Research Laboratories, Sankyo Co Ltd, Tokyo, Japan.
Stroke. 1993 Oct;24(10):1568-74; discussion 1574-5. doi: 10.1161/01.str.24.10.1568.
Although several local cerebral glucose utilization (LCGU) studies using rat forebrain ischemia models have been performed to date, none that investigate long-term postischemic changes in LCGU throughout the brain have been reported. We investigated postischemic changes throughout the brain over 14 days using a rat forebrain ischemia model.
Cerebral ischemia was produced using the rat four-vessel occlusion model. After 30 minutes of ischemia cerebral blood flow was restored, and LCGU in 34 structures in the brain was evaluated at 1, 3, 5, 7, and 14 days after ischemia.
LCGU changes were characterized and could be divided into two major patterns, type 1 and type 2. In type 1, LCGU was reduced remarkably at 1 and 3 days, and it returned to near the control level at 5 days. In type 2, LCGU was reduced mildly at 1 day and returned to near the control level at 3 days. Included in type 1 were the severely ischemic structures such as the cerebral cortices and striatum. Included in type 2 were the less severely ischemic structures such as the midbrain, cerebellum, and pons and medulla oblongata. Drastic changes in LCGU took place not only in gray matter but also in white matter, and the patterns of LCGU changes were similar in both regions. Atypical changes in LCGU were observed in the hippocampal CA1 and substantia nigra pars reticulata. In both structures, LCGU was remarkably increased around 7 days after ischemia.
There are two major patterns of LCGU changes after transient forebrain ischemia. LCGU changes in the hippocampal CA1 and substantia nigra pars reticulata are atypical.
尽管目前已经进行了多项使用大鼠前脑缺血模型的局部脑葡萄糖利用（LCGU）研究，但尚未有研究报道对全脑缺血后长期的LCGU变化进行调查。我们使用大鼠前脑缺血模型研究了全脑在缺血后14天内的变化。
采用大鼠四血管闭塞模型制造脑缺血。缺血30分钟后恢复脑血流，并在缺血后1、3、5、7和14天评估脑内34个结构的LCGU。
LCGU变化具有特征性，可分为两种主要模式，即1型和2型。在1型中，LCGU在第1天和第3天显著降低，在第5天恢复到接近对照水平。在2型中，LCGU在第1天轻度降低，在第3天恢复到接近对照水平。1型包括严重缺血的结构，如大脑皮质和纹状体。2型包括缺血较轻的结构，如中脑、小脑以及脑桥和延髓。LCGU的剧烈变化不仅发生在灰质中，也发生在白质中，并且两个区域的LCGU变化模式相似。在海马CA1区和黑质网状部观察到LCGU的非典型变化。在这两个结构中，缺血后约7天LCGU显著增加。
短暂性前脑缺血后LCGU变化有两种主要模式。海马CA1区和黑质网状部的LCGU变化是非典型的。
