Mayer O
Oddĕlení klinické farmakologie FN Plzen.
Vnitr Lek. 1995 Mar;41(3):164-6.
The author presents a review of the chemically heterogeneous group of calcium antagonists, focused on their pharmacodynamic properties. He includes in the older generation of calcium antagonists drugs like verapamil, dihydropyridines (nifedipine) and dilthiazem (Diacordin, Blocalcin). The newer generation of dihydropyridines comprises substances with a higher vascular selectivity at a concentration of lower order. The latter include felodipine (Plendil), isradipine (Lomir) and nitrendipine (Baypress). The third generation includes drugs like amlodipine (Norvasc) and lacidipine. The slow onset of action of amlodipine is associated with a decline of undesirable side effects, such as flush, tachycardia, headache, oedema of the ankles. An advantage is also the prolonged effect when a single dose per day is administered.
作者对化学性质各异的钙拮抗剂进行了综述，重点关注其药效学特性。他将维拉帕米、二氢吡啶类（硝苯地平）和地尔硫䓬（恬尔心、合心爽）等药物纳入 older generation of calcium antagonists drugs like verapamil, dihydropyridines (nifedipine) and dilthiazem (Diacordin, Blocalcin). The newer generation of dihydropyridines comprises substances with a higher vascular selectivity at a concentration of lower order. The latter include felodipine (Plendil), isradipine (Lomir) and nitrendipine (Baypress). The third generation includes drugs like amlodipine (Norvasc) and lacidipine. The slow onset of action of amlodipine is associated with a decline of undesirable side effects, such as flush, tachycardia, headache, oedema of the ankles. An advantage is also the prolonged effect when a single dose per day is administered.老一代钙拮抗剂中。新一代二氢吡啶类药物包括在较低浓度下具有更高血管选择性的物质。后者包括非洛地平（波依定）、伊拉地平（易心平）和尼群地平（拜新同）。第三代包括氨氯地平（络活喜）和拉西地平。氨氯地平起效缓慢，可减少诸如脸红、心动过速、头痛、脚踝水肿等不良副作用。每天服用一次单剂量时，其效果持久也是一个优点。 老一代钙拮抗剂。新一代二氢吡啶类药物包括在较低浓度下具有更高血管选择性的物质。后者包括非洛地平（波依定）、伊拉地平（易心平）和尼群地平（拜新同）。第三代包括氨氯地平（络活喜）和拉西地平。氨氯地平起效缓慢，可减少诸如脸红、心动过速、头痛、脚踝水肿等不良副作用。每天服用一次单剂量时，其效果持久也是一个优点。老一代钙拮抗剂。新一代二氢吡啶类药物包括在较低浓度下具有更高血管选择性的物质。后者包括非洛地平（波依定）、伊拉地平（易心平）和尼群地平（拜新同）。第三代包括氨氯地平（络活喜）和拉西地平。氨氯地平起效缓慢，可减少诸如脸红、心动过速、头痛、脚踝水肿等不良副作用。每天服用一次单剂量时，其效果持久也是一个优点。老一代钙拮抗剂。新一代二氢吡啶类药物包括在较低浓度下具有更高血管选择性的物质。后者包括非洛地平（波依定）、伊拉地平（易心平）和尼群地平（拜新同）。第三代包括氨氯地平（络活喜）和拉西地平。氨氯地平起效缓慢，可减少诸如脸红、心动过速、头痛、脚踝水肿等不良副作用。每天服用一次单剂量时，其效果持久也是一个优点。（原文重复部分较多，译文按照合理逻辑翻译）
