Aksenov O A, Murina E A, Kogan E M, Platonova G A, Sidorova N S, Timkovskiĭ A L
Vopr Virusol. 1995 Mar-Apr;40(2):56-9.
Modification of poly(G).poly(C) with cys-diaminodichloroplatinum (cys-DDP) at the level of rb = 0.02 increased the in vivo antiviral and interferon-inducing activity of the complex, in contrast to the data reported for complex poly(G).poly(C). Antiinfluenza activity in this case depends on the method of modification and increases more intensively when a ready complex is treated with cys-DDP, as against treatment of poly(G) alone before the formation of a complex with poly(C). If rb is increased, the activity reduces again. Modification with trans-DDP at rb = 0.02 also leads to an increase of antiinfluenza activity of poly(G).poly(C), but mainly after pretreatment of poly(G).
在rb = 0.02的水平下，用半胱氨酸二氨基二氯铂（cys-DDP）修饰聚（G）.聚（C），与报道的聚（G）.聚（C）复合物的数据相比，增加了该复合物的体内抗病毒和诱导干扰素活性。在这种情况下，抗流感活性取决于修饰方法，当用cys-DDP处理现成的复合物时，其活性增加更为强烈，这与在与聚（C）形成复合物之前单独处理聚（G）的情况相反。如果rb增加，活性会再次降低。在rb = 0.02时用反式-DDP修饰也会导致聚（G）.聚（C）的抗流感活性增加，但主要是在聚（G）预处理之后。
