Friedlander G N, Potter G K, Tucker R S, Berlin S J
Foot Care Surgicenter, Sun City, Arizona, USA.
Acta Cytol. 1995 May-Jun;39(3):586-8.
Histopathologic studies have demonstrated microshards from silicone elastomer metatarsophalangeal joint implants in adjacent tissues in a setting of chronic inflammation and in inguinal lymph nodes. Cytologic smears of synovial fluid from symptomatic implanted joints should show these refractile, nonpolarizing microshards in the reactive inflammatory context. Nonspecific enzymatic inflammatory activity contributes to further destabilization of the implants, eventuating in symptoms and signs requiring prosthesis removal. Cytopathologic examination of aspirated fluid from the vicinity of a symptomatic implanted joint demonstrates foreign body reaction to silicone elastomer, predicting a need for intervention before the local damage is severe and disabling.
组织病理学研究表明,在慢性炎症环境下,硅橡胶弹性体跖趾关节植入物的微碎片出现在相邻组织以及腹股沟淋巴结中。有症状的植入关节的滑液细胞学涂片应在反应性炎症背景下显示出这些折光性、非偏振性的微碎片。非特异性酶促炎症活动会导致植入物进一步不稳定,最终出现需要移除假体的症状和体征。对有症状的植入关节附近抽取的液体进行细胞病理学检查,可显示对硅橡胶弹性体的异物反应,这预示着在局部损伤严重且致残之前就需要进行干预。