Sacktor N, Prohovnik I, Van Heertum R L, Dooneief G, Gorman J, Marder K, Todak G, Stern Y, Mayeux R
Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA.
Arch Neurol. 1995 Jun;52(6):607-11. doi: 10.1001/archneur.1995.00540300081017.
To determine whether technetium Tc99m exametazime single-photon computed emission tomography (SPECT) can distinguish gay human immunodeficiency virus (HIV)-positive subjects, both with and without mild cognitive impairment, from gay HIV-negative control subjects.
Twenty HIV-positive subjects (12 without cognitive impairment and eight with mild cognitive impairment) and 10 HIV-negative subjects underwent neurological, neuropsychological, magnetic resonance imaging, and technetium Tc 99m exametazime SPECT examinations.
Subjects were recruited from a natural history study of gay men with HIV infection.
Subjects from the cohort who had previously participated in a magnetic resonance imaging study were selected for the SPECT study.
The SPECT scans were rated as abnormal if focal defects, confirmed by a horizontal profile analysis, were seen.
Sixty-seven percent of HIV-positive subjects without cognitive impairment, 88% of HIV-positive subjects with mild cognitive impairment, and 20% of HIV-negative subjects had abnormal SPECT scans (P < .05 for both HIV-positive groups when each group was compared with HIV-negative subjects).
Compared with gay HIV-negative control subjects, focal SPECT defects are seen with an increased frequency in HIV-positive gay men without cognitive impairment and in HIV-positive gay men with mild cognitive impairment.
确定锝 Tc99m 依沙美肟单光子发射计算机断层扫描（SPECT）能否区分男同性恋人类免疫缺陷病毒（HIV）阳性受试者（包括有和没有轻度认知障碍者）与男同性恋 HIV 阴性对照受试者。
20 名 HIV 阳性受试者（12 名无认知障碍，8 名有轻度认知障碍）和 10 名 HIV 阴性受试者接受了神经学、神经心理学、磁共振成像及锝 Tc99m 依沙美肟 SPECT 检查。
受试者来自一项男同性恋 HIV 感染自然史研究。
从先前参与过磁共振成像研究的队列中选取受试者进行 SPECT 研究。
若通过水平轮廓分析证实存在局灶性缺损，则 SPECT 扫描结果判定为异常。
无认知障碍的 HIV 阳性受试者中，67%的 SPECT 扫描结果异常；有轻度认知障碍的 HIV 阳性受试者中，88%的 SPECT 扫描结果异常；HIV 阴性受试者中，20%的 SPECT 扫描结果异常（两组 HIV 阳性受试者与 HIV 阴性受试者相比，P 均<0.05）。
与男同性恋 HIV 阴性对照受试者相比，无认知障碍的 HIV 阳性男同性恋者和有轻度认知障碍的 HIV 阳性男同性恋者中，SPECT 局灶性缺损的出现频率更高。
