Yamaguchi K, Tsuji T, Wakuri S, Yazawa K, Kondo K, Shigemori H, Kobayashi J
Sagami Chemical Research Center, Kanagawa, Japan.
Biosci Biotechnol Biochem. 1993 Feb;57(2):195-9. doi: 10.1271/bbb.57.195.
Fellutamide A, a tripeptide derivative from Penicillium fellutanum was found to be a potent enhancer of nerve growth factor (NGF) synthesis and secretion in vitro. This compound enhanced production of NGF in L-M cells, rat brain cells, and rat glial cells. The mode of action of this compound was suggested to be different from that of a known NGF inducer, epinephrine, as inducing activities of fellutamide A and epinephrine were additive when they were admixed at the concentration which gave saturation in its respective activity. Furthermore, fellutamide A but not epinephrine induced production of NGF in the rat brain cells. NGF-inducing activity of several tripeptides and other compounds related to fellutamide A was examined.
发现来源于费卢坦青霉的三肽衍生物费卢他胺A在体外是神经生长因子（NGF）合成和分泌的有效增强剂。该化合物增强了L-M细胞、大鼠脑细胞和大鼠神经胶质细胞中NGF的产生。该化合物的作用模式被认为与已知的NGF诱导剂肾上腺素不同，因为当费卢他胺A和肾上腺素以各自活性达到饱和的浓度混合时，它们的诱导活性是相加的。此外，费卢他胺A而非肾上腺素诱导大鼠脑细胞产生NGF。研究了几种三肽以及与费卢他胺A相关的其他化合物的NGF诱导活性。
