Paliwal S K, Nadler T K, Regnier F E
Department of Chemistry, Purdue University, West Lafayette, IN 47907.
Trends Biotechnol. 1993 Mar;11(3):95-101. doi: 10.1016/0167-7799(93)90058-H.
Detection of protein variants in the production of recombinant DNA products is an important and complex task. Rapid acquisition of this information permits feedback control of the production process and continuous validation of the product. Much of the technology required for rapid process monitoring is currently available or under development.
在重组DNA产品生产过程中检测蛋白质变体是一项重要且复杂的任务。快速获取此类信息有助于对生产过程进行反馈控制以及对产品进行持续验证。快速过程监测所需的许多技术目前已经具备或正在开发之中。