Ulaeto D, Hruby D E
Department of Microbiology, Oregon State University, Corvallis 97331-3804.
Curr Opin Biotechnol. 1994 Oct;5(5):501-4. doi: 10.1016/0958-1669(94)90064-7.
The construction of vaccinia-based vaccines has been hampered by a lack of information on both the mechanisms of vaccinia-induced immunity in humans and the effect of prior exposure to vaccinia on the course of an immune response to a non-vaccinia antigen. Recent studies have investigated the immune responses induced by this virus in humans and the ability of recombinant viruses to successfully induce immunity to diverse pathogens with diverse routes of infection. In addition to the previously described ability of vaccinia to induce immune responses in experimental animals, the virus has been shown to encode modulators of immune function that may, in the future, permit the use of virus to induce qualitatively different immune responses to particular heterologous antigens.
一是痘苗病毒在人体内诱导免疫的机制，二是先前接触痘苗病毒对针对非痘苗病毒抗原的免疫反应过程的影响。最近的研究调查了该病毒在人体内诱导的免疫反应，以及重组病毒通过不同感染途径成功诱导针对多种病原体的免疫的能力。除了先前描述的痘苗病毒在实验动物中诱导免疫反应的能力外，该病毒还被证明可编码免疫功能调节因子，未来可能允许利用该病毒诱导针对特定异源抗原的性质不同的免疫反应。
