Clark D S
Department of Chemical Engineering, University of California, Berkeley 94720.
Trends Biotechnol. 1994 Nov;12(11):439-43. doi: 10.1016/0167-7799(94)90018-3.
Immobilization has long been recognized as a useful tool for retaining enzymes in bioreactors and enabling the continuous operation of enzymic processes. However, the potential of immobilization for modifying enzyme activity in an advantageous, if not predictable, manner is less-well appreciated. This review summarizes selected studies that have used immobilization to tailor the catalytic properties of enzymes, and highlights the application of immobilization to the rational design of biocatalysts.
