Yang Z F, Yu S Q, Chen J Y
Institute of Chemical Metallurgy, Academia Sinica, Beijing, People's Republic of China.
J Chem Technol Biotechnol. 1994 Nov;61(3):247-50. doi: 10.1002/jctb.280610311.
A solvent mixture of 1-hexanol and butyl acetate has been successfully used for the extraction of penicillin G. This solvent mixture may not only synergistically and effectively extract penicillin G, but also inhibit emulsion formation during the extraction of penicillin G from the filtrate of the fermentation broth. The equilibrium constants of the extraction, the molar ratios of 1-hexanol and penicillin G in the extracted species and the synergistic extraction of penicillin G have been studied by chemical analysis and by monitoring the absorbency shift in the FT-IR spectra of the functional groups in the solvents.
己醇和乙酸丁酯的混合溶剂已成功用于青霉素G的萃取。这种混合溶剂不仅能协同有效地萃取青霉素G，还能抑制从发酵液滤液中萃取青霉素G过程中的乳化现象。通过化学分析以及监测溶剂中官能团的傅里叶变换红外光谱（FT-IR）的吸光度变化，研究了萃取的平衡常数、萃合物中己醇与青霉素G的摩尔比以及青霉素G的协同萃取情况。
