酚妥拉明可阻断生长抑素介导的胰岛素分泌抑制作用。
Phentolamine blocks the somatostatin-mediated inhibition of insulin secretion.
作者信息
Smith P H, Woods S C, Porte D
出版信息
Endocrinology. 1976 Apr;98(4):1073-6. doi: 10.1210/endo-98-4-1073.
PMID:776596
Abstract
This study was undertaken to determine the influence of alpha-adrenergic blockade upon the somatostatin-mediated inhibition of insulin secretion. Somatostatin inhibited both the basal and glucose-stimulated pancreaticoduodenal vein insulin output of dogs. This effect was not observed during a simultaneous infusion of phentolamine, an alpha-adrenergic blocker. It is proposed that alpha-adrenergic mechanisms play a role in the inhibition of insulin secretion by somatostatin.
摘要
本研究旨在确定α-肾上腺素能阻断对生长抑素介导的胰岛素分泌抑制作用的影响。生长抑素可抑制犬的基础及葡萄糖刺激的胰十二指肠静脉胰岛素分泌。在同时输注α-肾上腺素能阻滞剂酚妥拉明期间未观察到这种效应。有人提出，α-肾上腺素能机制在生长抑素抑制胰岛素分泌中起作用。
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