Miyahara K, Hirata D, Miyakawa T
Department of Fermentation Technology, Hiroshima University, Japan.
Biosci Biotechnol Biochem. 1995 Jan;59(1):147-9. doi: 10.1271/bbb.59.147.
The Saccharomyces cerevisiae gene YDR1/PDR5/STS1, which encodes a member of the ATP binding cassette (ABC) superfamily, is important for cross-resistance to apparently unrelated drugs. The expression of YDR1 is induced by various drugs and heat shock [Hirata et al., Curr. Genet., 26, 285-294 (1994)]. By deletion analysis of the 5'-noncoding region of the YDR1 gene, two drug responsive regions (-604 to -485 and -335 to -275) were identified with fluphenazine and cycloheximide. Three conserved palindrome sequences were found in these regions.
酿酒酵母基因YDR1/PDR5/STS1编码ATP结合盒（ABC）超家族的一个成员，对明显不相关药物的交叉抗性很重要。YDR1的表达受多种药物和热休克诱导[平田等人，《当代遗传学》，26，285 - 294（1994）]。通过对YDR1基因5'-非编码区的缺失分析，用氟奋乃静和环己酰亚胺鉴定出两个药物反应区域（-604至-485和-335至-275）。在这些区域发现了三个保守的回文序列。
