Stone E A, Manavalan S J, Zhang Y, Quartermain D
Department of Psychiatry, New York University School of Medicine, New York, USA.
Neuropsychopharmacology. 1995 Feb;12(1):65-71. doi: 10.1038/sj.npp.1380240.
Reduced central noradrenergic function has been implicated as a factor in reduced behavioral activity after stress. The present studies examined the role of reduced beta adrenergic neurotransmission in mediating this effect. This was done by testing the ability of beta receptor antagonists to mimic the behavioral actions of stress. Mice were subjected to stress or given various beta antagonists and tested for swimming behavior, locomotor activity, or grooming behavior. As previously reported, stress reduced swimming and locomotor activity and increased grooming. Both the nonselective antagonist, l-propranolol, and the beta-1 selective antagonist, betaxolol, produced the same effects as stress on all three measures. A beta-2 selective antagonist, ICI 118,551, was effective only on swimming, whereas a membrane stabilizing agent, d-propranolol, was effective only on grooming behavior. The peripherally active beta-1 antagonist, atenolol, was not effective on any measure. The nonspecific dopaminergic receptor blocker, fluphenazine, reduced locomotion but tended also to reduce grooming. The results indicate that blockade of beta-1 receptors in the CNS selectively mimics the action of stress on gross motor activity in mice and, along with previous data, suggest that stress leads to a relative deficiency in central beta-1 noradrenergic neurotransmission in these animals.
中枢去甲肾上腺素能功能降低被认为是应激后行为活动减少的一个因素。本研究探讨了β-肾上腺素能神经传递减少在介导这一效应中的作用。这是通过测试β受体拮抗剂模拟应激行为作用的能力来完成的。对小鼠施加应激或给予各种β拮抗剂，并测试其游泳行为、运动活动或梳理行为。如先前报道，应激会降低游泳和运动活动，并增加梳理行为。非选择性拮抗剂l-普萘洛尔和β-1选择性拮抗剂倍他洛尔在所有三项指标上产生的效果与应激相同。β-2选择性拮抗剂ICI 118,551仅对游泳有效，而膜稳定剂d-普萘洛尔仅对梳理行为有效。外周活性β-1拮抗剂阿替洛尔对任何指标均无效。非特异性多巴胺能受体阻滞剂氟奋乃静减少了运动，但也倾向于减少梳理行为。结果表明，中枢神经系统中β-1受体的阻断选择性地模拟了应激对小鼠总体运动活动的作用，并且与先前的数据一起表明，应激导致这些动物中枢β-1去甲肾上腺素能神经传递相对不足。
