Goldenberg D L
Newton-Wellesley and Tufts University School of Medicine, Massachusetts, USA.
Curr Opin Rheumatol. 1995 Mar;7(2):127-35. doi: 10.1097/00002281-199503000-00011.
Two important studies in which nuclear magnetic resonance spectroscopy was used convincingly demonstrated that muscle is not the primary pathologic factor in fibromyalgia. There were further studies reporting that fibromyalgia-chronic fatigue syndrome may follow well treated Lyme disease or mimic Lyme disease. The longest therapeutic trial to date in fibromyalgia demonstrated an initial modest effect of tricyclic medications, but at 6 months that efficacy was no longer evident. Investigation in both fibromyalgia and chronic fatigue syndrome now focuses on the central nervous system. The use of new technology, eg, neurohormonal assays and imaging such as single-photon emission computed tomography scan, may be important in understanding these elusive conditions.
两项令人信服地使用核磁共振波谱法的重要研究表明，肌肉并非纤维肌痛的主要病理因素。还有进一步的研究报告称，纤维肌痛-慢性疲劳综合征可能发生在莱姆病得到良好治疗之后，或者与莱姆病症状相似。迄今为止针对纤维肌痛进行的最长治疗试验表明，三环类药物最初有一定程度的疗效，但在6个月时这种疗效不再明显。目前对纤维肌痛和慢性疲劳综合征的研究都集中在中枢神经系统。使用新技术，如神经激素测定和单光子发射计算机断层扫描等成像技术，可能对理解这些难以捉摸的病症很重要。
