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[迟发性先天性青光眼伴虹膜高附着的显性遗传]

[Dominant heredity in tardive congenital glaucoma with high insertion of the iris].

作者信息

Cernea P, Preoteasa D

机构信息

Clinique Ophtalmologique Craiova.

出版信息

Oftalmologia. 1995 Jan-Mar;39(1):37-43, 46-8.

PMID:7766577
Abstract

Seven cases of tardive congenital glaucoma determined by a high insertion of the iris are analyzed. Biomicroscopy revealed in all cases irian stromal atrophy and the complete or incomplete, total or partial insertion of the iris at the level of trabeculum was gonioscopically observed. With respect to the reducing of trabecular space exposed to aqueous humour, tension increase appeared between 11 and 20 years old at three patients, between 21 and 30 years old at three patients and at 34 years old at one patient. The authors consider the age of 35 to be an age limit in tardive congenital glaucoma. The transmission was dominant with variable expressivity. The systematic examination of family members allowed the discovering of other cases of tardive congenital glaucoma, which were unknown or known as open-angle glaucoma cases. The associations between tardive congenital glaucoma and myopia delayed the setting of diagnosis which lead to a more serious evolution. In the therapy with myotics was not sufficient, protected filtering interventions and especially trepanotrabeculectomy were recommended.

摘要

分析了7例因虹膜高位附着所致的迟发性先天性青光眼病例。生物显微镜检查在所有病例中均显示虹膜基质萎缩,前房角镜检查可见虹膜在小梁水平完全或不完全、全部或部分附着。关于暴露于房水的小梁间隙减小,3例患者在11至20岁时眼压升高,3例患者在21至30岁时眼压升高,1例患者在34岁时眼压升高。作者认为35岁是迟发性先天性青光眼的年龄界限。其遗传方式为显性遗传,表现度可变。对家庭成员的系统检查发现了其他迟发性先天性青光眼病例,这些病例之前未知或被认为是开角型青光眼病例。迟发性先天性青光眼与近视的关联延误了诊断的确立,导致病情进展更严重。使用缩瞳剂治疗效果不佳,建议采用保护性滤过干预措施,尤其是小梁切除术。

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