Henderson S R, Bonnar J, Moore A, Mackinnon P C
Fertil Steril. 1976 Jun;27(6):621-7. doi: 10.1016/s0015-0282(16)41890-x.
Five patients with primary infertility and secondary amenorrhea who did not respond to clomiphene with a gonadotropin or estrogen surge were treated with 500 mug of luteinizing hormone, follicle-stimulating hormone-releasing hormone (LH-RH), self-administered subcutaneously every 8 hours for 14 days. Of four patients who responded to this treatment, three showed follicular maturation, ovulation, and menses, although the luteal phase was deficient; in the fourth patient, follicular maturation and menses occurred without evidence of ovulation. For their second course of treatment these four patients were given LH-RH with the addition of human chorionic gonadotropin when the urinary estrogen levels indicated follicular maturation. All four patients responded with ovulation, an adequate luteal phase, and menses, without clinical indication of ovarian hyperstimulation. These results suggest that LH-RH may be a better alternative to human menopausal gonadotropin in the treatment of anovulatory infertility.
五名原发性不孕和继发性闭经患者对克罗米芬无反应，促性腺激素或雌激素未出现激增，给予500微克促黄体生成素、促卵泡激素释放激素（LH-RH），每8小时皮下自我注射一次，共14天。在对该治疗有反应的四名患者中，三名出现卵泡成熟、排卵和月经，尽管黄体期不足；第四名患者出现卵泡成熟和月经，但无排卵迹象。在第二个疗程中，当尿雌激素水平表明卵泡成熟时，这四名患者接受LH-RH治疗，并加用人绒毛膜促性腺激素。所有四名患者均出现排卵、黄体期充足和月经，无卵巢过度刺激的临床迹象。这些结果表明，在治疗无排卵性不孕症方面，LH-RH可能是人类绝经期促性腺激素的更好替代品。
