Kuzhir T D, Goncharova R I
Vestn Ross Akad Med Nauk. 1995(1):20-9.
1.4-Dihydroisonicotinic acid derivatives were used as an example to examine the mechanisms of action of exogenous antimutagens in chemical mutagenesis in eukaryotic organisms. The chemical mutagenesis was stimulated by alkylating agents, mutagens of direct action. The behaviour of alkylating mutagenesis was analysed, which gives an insight into the stages at which antimutagens may be involved in this process. Chemical mutagenesis was demonstrated to be suppressed due to lower molecular doses of the mutagen and by affecting the mechanisms of implementation of chemically induced mutations. Great emphasis was laid on the mechanisms of action of mutagens mediated by the intracellular antimutagenic and reparative systems. A special role is played by the analysis of exogenous antimutagens affecting DNA reparation as the most important step in the process of conversion of primary damages to fixed mutations. The paper presents a review of literature on basic problems of chemical mutagenesis modification.
以1,4 - 二氢异烟酸衍生物为例，研究真核生物化学诱变中外源抗诱变剂的作用机制。化学诱变由烷基化剂（直接作用的诱变剂）引发。分析了烷基化诱变的行为，这有助于深入了解抗诱变剂可能参与该过程的阶段。结果表明，较低分子剂量的诱变剂以及通过影响化学诱导突变的实施机制可抑制化学诱变。重点研究了由细胞内抗诱变和修复系统介导的诱变剂作用机制。分析影响DNA修复的外源抗诱变剂起着特殊作用，因为这是将初始损伤转化为固定突变过程中最重要的一步。本文综述了有关化学诱变修饰基本问题的文献。
