Drzhevetskiĭ Iu M, Poliak R I, Briskin A I
Fiziol Zh SSSR Im I M Sechenova. 1976 May;62(5):762-7.
In male rats, i. m. administration of thyrocalcitonin (TCT)--2 and 10 units/kg for 1, 5, 10 and 15 days, reduced calcium level in the blood serum. In the TCT-treated rats the glucose-tolerance curves after i. p. injection of glucose became diabetoid-like. TCT inhibited the increase of insulin-like activity of the serum after glucose injection. The data suggest that TCT, lowering the calcium content of blood serum, inhibited the glucose-induced secretion of insulin.
在雄性大鼠中，肌肉注射降钙素（TCT）——剂量为2和10单位/千克，持续1、5、10和15天，可降低血清钙水平。在接受TCT治疗的大鼠中，腹腔注射葡萄糖后的糖耐量曲线变得类似糖尿病样。TCT抑制了注射葡萄糖后血清胰岛素样活性的增加。这些数据表明，降低血清钙含量的TCT抑制了葡萄糖诱导的胰岛素分泌。
