Eur J Cancer Prev. 1995 Apr;4(2):175-80.
The incidence of Helicobacter pylori was compared in high and low risk gastric cancer areas. Complete data were available on 116 age and sex matched sets of cases--patients with histologically proven intestinal metaplasia (IM)--and two control groups, one non-IM endoscoped controls (EC) and one non-endoscoped controls (NC) recruited from out-patient clinics. H. pylori status was determined by both serology and histology in individuals biopsied from three separate gastric sites. Our data show an increased incidence of H. pylori and intestinal metaplasia in areas at high risk for gastric cancer, good agreement on H. pylori status between histology and serology and a relationship between H. pylori status in individual biopsies and the degree of gastritis. With 116 matched sets of patients this is one of the largest series to date and supports the hypothesis that H. pylori infection may be involved in gastric carcinogenesis through chronic gastritis and intestinal metaplasia.
对胃癌高风险地区和低风险地区的幽门螺杆菌感染率进行了比较。共有116对年龄和性别匹配的病例数据——组织学确诊为肠化生（IM）的患者——以及两个对照组，一个是未发生肠化生的内镜检查对照组（EC），另一个是从门诊招募的非内镜检查对照组（NC）。通过血清学和组织学方法对从三个不同胃部位活检的个体进行幽门螺杆菌状态检测。我们的数据显示，胃癌高风险地区幽门螺杆菌感染率和肠化生发生率均升高，组织学和血清学对幽门螺杆菌状态的检测结果一致性良好，且个体活检的幽门螺杆菌状态与胃炎程度之间存在关联。本研究纳入了116对匹配患者，是迄今为止规模最大的系列研究之一，支持幽门螺杆菌感染可能通过慢性胃炎和肠化生参与胃癌发生的假说。
