Hung J C, Wilson M E
Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Nucl Med Biol. 1995 Feb;22(2):227-9. doi: 10.1016/0969-8051(94)00087-z.
The standard high pressure liquid chromatography (HPLC) method for determining radiochemical purity (RCP) of [131I]m-iodobenzylguanidine ([131I]mIBG) is cumbersome and time-consuming. A simplified and rapid separation method with the use of a reverse-phase extraction chromatography technique (i.e. Sep-Pak C18 [SPC] cartridge) is described. The new SPC system closely correlates (r = 0.99) to the standard HPLC method, and the time to complete the SPC analysis is less than 5 min.
用于测定[131I]间碘苄胍（[131I]mIBG）放射化学纯度（RCP）的标准高压液相色谱（HPLC）方法既繁琐又耗时。本文描述了一种使用反相萃取色谱技术（即Sep-Pak C18 [SPC] 柱）的简化快速分离方法。新的SPC系统与标准HPLC方法密切相关（r = 0.99），完成SPC分析的时间不到5分钟。
