Samsonov M Y, Tilz G P, Egorova O, Reibnegger G, Balabanova R M, Nassonov E L, Nassonova V A, Wachter H, Fuchs D
Laboratory of Clinical Immunology, Cardiology Research Center, Moscow, Russia.
Lupus. 1995 Feb;4(1):29-32. doi: 10.1177/096120339500400107.
We investigated a possible association between markers of immune activation and disease activity in 52 patients with systemic lupus erythematosus (SLE). Serum concentrations of neopterin, beta-2-microglobulin, 55 kD-type soluble tumor necrosis factor receptor, soluble interleukin-2 receptor and soluble CD8 were compared to the Index of European Consensus Lupus Activity Measurement (ECLAM). All markers of immune activation, except sCD8, significantly correlated with ECLAM. Stepwise multiple linear regression analysis revealed erythrocyte sedimentation rate and neopterin to correlate best with ECLAM (multiple correlation coefficient = 0.74, P < 0.001). The study shows that serum neopterin concentrations are a useful independent index for disease activity in SLE. The finding of enhanced concentrations of various parameters of immune activation in patients confirm a role of the T cell and macrophage activation in the pathogenesis of SLE.
我们调查了52例系统性红斑狼疮（SLE）患者免疫激活标志物与疾病活动度之间的可能关联。将血清新蝶呤、β2微球蛋白、55 kD型可溶性肿瘤坏死因子受体、可溶性白细胞介素-2受体和可溶性CD8的浓度与欧洲狼疮活动度测量共识指数（ECLAM）进行比较。除可溶性CD8外，所有免疫激活标志物均与ECLAM显著相关。逐步多元线性回归分析显示红细胞沉降率和新蝶呤与ECLAM的相关性最佳（多元相关系数=0.74，P<0.001）。该研究表明，血清新蝶呤浓度是SLE疾病活动度的一个有用的独立指标。患者体内多种免疫激活参数浓度升高的发现证实了T细胞和巨噬细胞激活在SLE发病机制中的作用。
