Chaumont A, Wodey E, Joly A, Lucas M M, Carre P
Département d'Anesthésie-Réanimation, CHRU Pontchaillou, Rennes.
Cah Anesthesiol. 1994;42(6):751-6.
Some new theories concerning pain physiology have recently been suggested. Experimental facts show that despite its complexity, neuroplasticity is an established fact. The concept of preemptive analgesia is about to receive clinical applications. Nevertheless, the role of many opioid ligands which are involved in the pain physiology can explain the efficacy of some analgesia techniques. The authors review the physiological process of pain from its periphery to its centre and the ensuing practical applications. They point out the difficulty to apprehend peripheral analgesia, and the necessity of further researches concerning especially NMDA spinal receptors and other specific receptors.
最近有人提出了一些关于疼痛生理学的新理论。实验事实表明,尽管神经可塑性很复杂,但它是一个既定事实。超前镇痛的概念即将得到临床应用。然而,许多参与疼痛生理学的阿片样物质配体的作用可以解释一些镇痛技术的疗效。作者回顾了从疼痛外周到中枢的生理过程以及随之而来的实际应用。他们指出了理解外周镇痛的困难,以及对尤其是NMDA脊髓受体和其他特定受体进行进一步研究的必要性。