赞比亚卢萨卡恶性疟原虫疟疾的体内药物敏感性
Plasmodium falciparum malaria in vivo drug sensitivity in Lusaka, Zambia.
作者信息
Blom G J, Baboo K S, Athale U H, van der Werf T S
机构信息
Department of Internal Medicine, Sophia Hospital, Zwolie, The Netherlands.
出版信息
Cent Afr J Med. 1995 Jan;41(1):6-10.
In most of sub-Saharan African, drug resistant falciparum malaria has become a major health care concern. Drug sensitivity was evaluated in vivo in Lusaka, Zambia, in 71 episodes in 61 patients with uncomplicated falciparum malaria, for Chloroquin (CQ), Pyrimethamine/sulfadoxine (PS) and halofantrine (HF). CQ resistance was found at R2 (16 pc) and R3 (24.5 pc) level in 37 patients, R3 (10.5 pc) resistance to PS was found among 19 subjects studied. The drug resistance to CQ was inversely related to age.
在撒哈拉以南非洲的大部分地区，耐药性恶性疟疾已成为主要的医疗保健问题。1996年在赞比亚卢萨卡，对61例非复杂性恶性疟疾病人的71次发作进行了氯喹（CQ）、乙胺嘧啶/磺胺多辛（PS）和卤泛群（HF）的体内药物敏感性评估。在37例病人中发现有R2（16%）和R3（24.5%）水平的CQ耐药性，在所研究的19例对象中发现有10.5%的PS耐药性。对CQ的耐药性与年龄呈负相关。
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