Merrill J E, Jonakait G M
Department of Neurology, University of California at Los Angeles, School of Medicine 90024, USA.
FASEB J. 1995 May;9(8):611-8. doi: 10.1096/fasebj.9.8.7768352.
Neurotransmitters, neuropeptides, neurotrophins, and neuroendocrine hormones have traditionally been assigned functions in normal development and homeostasis of neuronal networks; cytokines and adhesion molecules have been assigned functions within the peripheral immune system. Molecular dissection of the presence and function of these receptors and ligands during development of the immune and nervous systems, in normal healthy adult central and peripheral nervous tissue, and in the pathological response of immune elements in the brain and neuroelements in the immune system has forced us to alter these long-held concepts. Examples of how glia and neurons function in relationship to these paracrine and autocrine stimuli in health and disease are provided in this short review.
传统上，神经递质、神经肽、神经营养因子和神经内分泌激素被认为在神经网络的正常发育和稳态中发挥作用；细胞因子和黏附分子则被认为在外周免疫系统中发挥作用。对这些受体和配体在免疫和神经系统发育过程中、正常健康成年中枢和外周神经组织中以及大脑中免疫成分和免疫系统中神经成分的病理反应中的存在和功能进行分子剖析，迫使我们改变这些长期以来的观念。本简短综述提供了神经胶质细胞和神经元在健康和疾病状态下如何与这些旁分泌和自分泌刺激相互作用的实例。
