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在用麻风分枝杆菌和海分枝杆菌感染足垫的小鼠中存在全身和局部活化的巨噬细胞。

The presence of systemic and local activated macrophages in mice infected in the foot pad with Mycobacterium leprae and M. marinum.

作者信息

Krahenbuhl J L, Welch T M, Levy L

出版信息

Int J Lepr Other Mycobact Dis. 1976 Jan-Jun;44(1-2):206-15.

PMID:776858
Abstract

A highly sensitive assay for quantitating the presence of activated macrophages was employed to show that foot pad infection of mice with neither M. leprae nor M. marinum induced a population of activated peritoneal macrophages. In vitro attempts to demonstrate local activated macrophages in the foot pads of M. leprae infected mice failed, but, because of the technical problems encountered, do not preclude their presence. Additional studies are being carried out.

摘要

采用一种高度灵敏的检测方法来定量活化巨噬细胞的存在,结果显示,用麻风杆菌或海鱼分枝杆菌感染小鼠足垫,均不会诱导产生一群活化的腹腔巨噬细胞。在体外试验中,试图证明麻风杆菌感染小鼠足垫中存在局部活化巨噬细胞,但未成功,不过,由于遇到技术问题,这并不排除它们的存在。正在开展进一步的研究。

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