幽门螺杆菌定殖的无菌仔猪胃溃疡的发生情况。
Occurrence of gastric ulcers in gnotobiotic piglets colonized by Helicobacter pylori.
作者信息
Krakowka S, Eaton K A, Rings D M
机构信息
Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, USA.
出版信息
Infect Immun. 1995 Jun;63(6):2352-5. doi: 10.1128/iai.63.6.2352-2355.1995.
Abstract
Archival gastric tissues from 10 of 39 gnotobiotic piglets colonized with Helicobacter pylori 26695 contained stromal leukocytic inflammation along with ulcers and erosions. In contrast, gastric tissues from 54 archival control piglets were devoid of both inflammation and ulcers. These data confirm the hypothesis that H. pylori infection alone is ulcerogenic.
摘要
在39只定殖有幽门螺杆菌26695的悉生仔猪中，10只的存档胃组织存在基质白细胞炎症，伴有溃疡和糜烂。相比之下，54只存档对照仔猪的胃组织既没有炎症也没有溃疡。这些数据证实了仅幽门螺杆菌感染就会导致溃疡的假说。
相似文献
1
Occurrence of gastric ulcers in gnotobiotic piglets colonized by Helicobacter pylori.
Infect Immun. 1995 Jun;63(6):2352-5. doi: 10.1128/iai.63.6.2352-2355.1995.
2
Virulence of coccoid and bacillary forms of Helicobacter pylori in gnotobiotic piglets.
J Infect Dis. 1995 Feb;171(2):459-62. doi: 10.1093/infdis/171.2.459.
3
Reproduction of severe gastroesophageal ulcers (GEU) in gnotobiotic swine infected with porcine Helicobacter pylori-like bacteria.
Vet Pathol. 2006 Nov;43(6):956-62. doi: 10.1354/vp.43-6-956.
4
Experimental induction of bacterial gastritis and gastric ulcer disease in gnotobiotic swine inoculated with porcine Helicobacter-like species.
Am J Vet Res. 2005 Jun;66(6):945-52. doi: 10.2460/ajvr.2005.66.945.
5
Adaptive mutation and cocolonization during Helicobacter pylori infection of gnotobiotic piglets.
Infect Immun. 1995 Jan;63(1):116-21. doi: 10.1128/iai.63.1.116-121.1995.
6
[The effect of Helicobacter pylori infection and duodenogastric reflux on the histology of gastric mucosa in peptic ulcers].
Folia Med Cracov. 1996;37(1-2):3-14.
7
Helicobacter pylori, gastric ulcer, and agents noxious to the gastric mucosa.
Gastroenterol Clin North Am. 1993 Mar;22(1):117-25.
8
Gastritis associated with infection by Helicobacter pylori: comparative pathology in humans and swine.
Rev Infect Dis. 1991 Jul-Aug;13 Suppl 8:S714-22. doi: 10.1093/clinids/13.supplement_8.s714.
9
Mucosal erosions in longterm non-steroidal anti-inflammatory drug users: predisposition to ulceration and relation to Helicobacter pylori.
Gut. 1995 Mar;36(3):334-6. doi: 10.1136/gut.36.3.334.
10
[H. pylori-infected Mongolian gerbil model].
Nihon Rinsho. 2002 Feb;60 Suppl 2:729-34.
引用本文的文献
1
Galacto-oligosaccharides improve barrier function and relieve colonic inflammation via modulating mucosa-associated microbiota composition in lipopolysaccharides-challenged piglets.
J Anim Sci Biotechnol. 2021 Aug 11;12(1):92. doi: 10.1186/s40104-021-00612-z.
2
Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models.
Dis Model Mech. 2017 Feb 1;10(2):89-104. doi: 10.1242/dmm.027649.
3
Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses.
Infect Immun. 2013 Oct;81(10):3803-13. doi: 10.1128/IAI.00660-13. Epub 2013 Jul 29.
4
Detection of Helicobacter spp. in gastric, fecal and saliva samples from swine affected by gastric ulceration.
J Vet Sci. 2010 Sep;11(3):221-5. doi: 10.4142/jvs.2010.11.3.221.
5
Pathogenesis of Helicobacter pylori infection.
Clin Microbiol Rev. 2006 Jul;19(3):449-90. doi: 10.1128/CMR.00054-05.
6
Effects of metronidazole, tetracycline, and bismuth-metronidazole-tetracycline triple therapy in the Helicobacter pylori SS1 mouse model after 1 day of dosing: development of an H. pylori lead selection model.
Antimicrob Agents Chemother. 2002 May;46(5):1435-40. doi: 10.1128/AAC.46.5.1435-1440.2002.
7
Experimental infection of Mongolian gerbils with wild-type and mutant Helicobacter pylori strains.
Infect Immun. 1998 Oct;66(10):4856-66. doi: 10.1128/IAI.66.10.4856-4866.1998.
8
Antimicrobial therapies for Helicobacter pylori infection in gnotobiotic piglets.
Antimicrob Agents Chemother. 1998 Jul;42(7):1549-54. doi: 10.1128/AAC.42.7.1549.
9
Pathological changes in the formation of Helicobacter pylori-induced gastric lesions in Mongolian gerbils.
Dig Dis Sci. 1998 Apr;43(4):754-65. doi: 10.1023/a:1018861930068.
10
Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets.
Infect Immun. 1997 Aug;65(8):3462-4. doi: 10.1128/iai.65.8.3462-3464.1997.
本文引用的文献
1
Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5791-5. doi: 10.1073/pnas.90.12.5791.
2
Incidence of Helicobacter pylori strains activating neutrophils in patients with peptic ulcer disease.
Gut. 1993 May;34(5):599-603. doi: 10.1136/gut.34.5.599.
3
Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production.
Infect Immun. 1993 May;61(5):1799-809. doi: 10.1128/iai.61.5.1799-1809.1993.
4
Pathogenicity of Helicobacter pylori: a perspective.
Infect Immun. 1993 May;61(5):1601-10. doi: 10.1128/iai.61.5.1601-1610.1993.
5
Ulcers as an infectious disease.
Science. 1993 Apr 9;260(5105):159-60. doi: 10.1126/science.8469968.
6
Epizootic gastritis associated with gastric spiral bacilli in cheetahs (Acinonyx jubatus).
Vet Pathol. 1993 Jan;30(1):55-63. doi: 10.1177/030098589303000107.
7
Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer.
N Engl J Med. 1993 Feb 4;328(5):308-12. doi: 10.1056/NEJM199302043280503.
8
Distribution of Helicobacter pylori colonisation and associated gastric inflammatory changes: difference between patients with duodenal and gastric ulcers.
J Clin Pathol. 1993 Aug;46(8):754-6. doi: 10.1136/jcp.46.8.754.
9
Production of chemoattractant by Helicobacter pylori.
Dig Dis Sci. 1993 Sep;38(9):1697-701. doi: 10.1007/BF01303180.
10
Role of Helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer.
Scand J Gastroenterol Suppl. 1993;196:3-6. doi: 10.3109/00365529309098333.
Zotero 插件