牙龈卟啉单胞菌菌毛在体外刺激的骨吸收受到酪氨酸激酶抑制剂的抑制。
Porphyromonas gingivalis fimbria-stimulated bone resorption in vitro is inhibited by a tyrosine kinase inhibitor.
作者信息
Hanazawa S, Kawata Y, Murakami Y, Naganuma K, Amano S, Miyata Y, Kitano S
机构信息
Department of Oral Microbiology, Meikai University School of Dentistry, Sakado City, Japan.
出版信息
Infect Immun. 1995 Jun;63(6):2374-7. doi: 10.1128/iai.63.6.2374-2377.1995.
Abstract
Our previous study (Y. Kawata, S. Hanazawa, S. Amano, Y. Murakami, T. Matsumoto, K. Nishida, and S. Kitano, Infect. Immun. 62:3012-3016, 1994) showed that Porphyromonas gingivalis fimbriae stimulate bone resorption in vitro. Since it has recently been demonstrated that tyrosine kinase encoded by the c-src gene plays an important role in osteoclastic bone resorption, in the present study we examined the effect of a tyrosine kinase inhibitor on the fimbria-stimulated bone resorption. Genistein, a potent inhibitor of tyrosine kinase, markedly inhibited bone resorption stimulated by the fimbriae. Genistein also inhibited induction of several tyrosine-phosphorylated proteins in the fimbria-treated calvarial bone cells from mouse embryos.
摘要
我们之前的研究（Y. 川田、S. 花泽、S. 天野、Y. 村上、T. 松本、K. 西田和S. 北野，《感染与免疫》62:3012 - 3016，1994年）表明牙龈卟啉单胞菌菌毛在体外可刺激骨吸收。由于最近已证明由c-src基因编码的酪氨酸激酶在破骨细胞性骨吸收中起重要作用，因此在本研究中，我们检测了酪氨酸激酶抑制剂对菌毛刺激的骨吸收的影响。染料木黄酮是一种有效的酪氨酸激酶抑制剂，它能显著抑制菌毛刺激的骨吸收。染料木黄酮还能抑制来自小鼠胚胎的经菌毛处理的颅骨细胞中几种酪氨酸磷酸化蛋白的诱导。
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