Allen L J, George L W, Willits N H
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Am Vet Med Assoc. 1995 Apr 15;206(8):1200-3.
To evaluate the efficacy of penicillin or penicillin and dexamethasone for treatment of infectious bovine keratoconjunctivitis, 6- to 8-month-old beef heifers with clinical signs of infectious bovine keratoconjunctivitis were randomly assigned to 1 of 3 treatment groups: penicillin only, penicillin and dexamethasone, or control. Cattle assigned to the penicillin group (n = 18) were treated with 3 daily subconjunctival injections of procaine penicillin G. Cattle assigned to the penicillin/dexamethasone group (n = 13) were treated with 3 daily subconjunctival injections of procaine penicillin G and dexamethasone sodium phosphate. Control cattle (n = 14) were not treated. Healing times and frequency of recurrence for corneal ulcers; severity, diameter, and surface area measurements of corneal ulcers; and clinical scores did not differ among the 3 groups. Frequency of Moraxella bovis isolation from specimens of ocular secretions from ulcerated and non-ulcerated eyes was similar in all groups. Minimum inhibitory concentration of penicillin G for 95 of the 102 tested M bovis isolates was 0.3 U/ml, and for 7 others was 0.03 U/ml. When first and last specimens from 42 of 45 calves with isolation of M bovis on serial microbial cultures were compared, the susceptibility of each last isolate was similar to that of the corresponding first isolate.
为评估青霉素或青霉素与地塞米松治疗牛传染性角膜结膜炎的疗效，将有牛传染性角膜结膜炎临床症状的6至8月龄肉用小母牛随机分为3个治疗组之一：仅用青霉素组、青霉素与地塞米松组或对照组。分配到青霉素组（n = 18）的牛每天进行3次结膜下注射普鲁卡因青霉素G。分配到青霉素/地塞米松组（n = 13）的牛每天进行3次结膜下注射普鲁卡因青霉素G和磷酸地塞米松钠。对照组牛（n = 14）不进行治疗。3组之间角膜溃疡的愈合时间和复发频率；角膜溃疡的严重程度、直径和表面积测量值；以及临床评分均无差异。所有组中，从溃疡眼和未溃疡眼的眼分泌物标本中分离出牛莫拉菌的频率相似。102株受试牛莫拉菌分离株中有95株对青霉素G的最低抑菌浓度为0.3 U/ml，另有7株为0.03 U/ml。对45头在系列微生物培养中分离出牛莫拉菌的犊牛中的42头的首次和末次标本进行比较时，每个末次分离株的敏感性与相应的首次分离株相似。
