肽抗生素微菌素25通过托品B途径和SbmA蛋白导入。
The peptide antibiotic microcin 25 is imported through the TonB pathway and the SbmA protein.
作者信息
Salomón R A, Farías R N
机构信息
Departamento de Bioquímica de la Nutrición, Instituto Superior de Investigaciones Biológicas (Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Nacional de Tucumán, Argentina.
出版信息
J Bacteriol. 1995 Jun;177(11):3323-5. doi: 10.1128/jb.177.11.3323-3325.1995.
Abstract
Selection of spontaneous mutants for insensitivity to the peptide antibiotic microcin 25 led to the isolation of five categories of mutants. Phenotypic and mapping studies showed the mutations to be located in the fhuA, exb, tonB, and sbmA genes. The latter encodes a cytoplasmic membrane protein which is also required for the penetration of microcin B17.
摘要
通过选择对肽抗生素微菌素25不敏感的自发突变体，分离出了五类突变体。表型和定位研究表明，这些突变位于fhuA、exb、tonB和sbmA基因中。后者编码一种细胞质膜蛋白，微菌素B17的穿透也需要该蛋白。
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