Salomón R A, Farías R N
Departamento de Bioquímica de la Nutrición, Instituto Superior de Investigaciones Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas-UNT, Tucumán, Argentina.
J Bacteriol. 1993 Dec;175(23):7741-2. doi: 10.1128/jb.175.23.7741-7742.1993.
A chromosomal Tn5 insertion resulting in complete resistance to the peptide antibiotic microcin 25 was mapped to the min 4 region of the Escherichia coli genetic map. Additional experiments showed that the insertion disrupted the fhuA gene, which encodes the multifunctional outer membrane receptor for ferrichrome, the antibiotic albomycin, colicin M, and bacteriophages T5, T1, and phi 80. Thus, microcin 25 and all of these agents share the same receptor.
一个导致对肽抗生素微菌素25完全耐药的染色体Tn5插入片段被定位到大肠杆菌遗传图谱的4分钟区域。进一步的实验表明，该插入破坏了fhuA基因，该基因编码铁载体、抗生素白霉素、大肠杆菌素M以及噬菌体T5、T1和φ80的多功能外膜受体。因此，微菌素25和所有这些因子共用相同的受体。
