Ikeda K, Ogata E
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
J Cell Biochem. 1995 Mar;57(3):384-91. doi: 10.1002/jcb.240570303.
Humoral hypercalcemia of malignancy (HHM) is a common paraneoplastic syndrome mediated by tumor-derived parathyroid hormone-related peptide (PTHRP), which bears structural and functional similarities to PTH. Thus the clinical features of HHM are very similar to those of primary hyperparathyroidism (1 degree HPT), a prototype of humoral hypercalcemia caused by PTH. On the other hand, HHM syndrome differs from 1 degree HPT in several aspects, including serum 1,25(OH)2D levels, acid-base balance, and bone remodeling process, the reason of which remains largely unknown. We approached these questions using a unique animal model of HHM, nude rats implanted with PTHRP-overproducing human carcinomas. In this review we will summarize the results and discuss the implications in understanding the disease mechanism.
恶性肿瘤体液性高钙血症（HHM）是一种常见的副肿瘤综合征，由肿瘤衍生的甲状旁腺激素相关肽（PTHRP）介导，该肽与甲状旁腺激素（PTH）在结构和功能上相似。因此，HHM的临床特征与原发性甲状旁腺功能亢进症（1度HPT）非常相似，原发性甲状旁腺功能亢进症是由PTH引起的体液性高钙血症的典型代表。另一方面，HHM综合征在几个方面与1度HPT不同，包括血清1,25(OH)2D水平、酸碱平衡和骨重塑过程，其原因在很大程度上仍然未知。我们使用一种独特的HHM动物模型来解决这些问题，即植入产生PTHRP的人类癌细胞的裸鼠。在这篇综述中，我们将总结结果并讨论其对理解疾病机制的意义。
