Graham B S, Tang Y W, Gruber W C
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2605, USA.
J Infect Dis. 1995 Jun;171(6):1468-74. doi: 10.1093/infdis/171.6.1468.
The modulatory effects of passive antibody on viral replication, illness, and immunity were investigated in a murine model of respiratory syncytial virus (RSV) infection. Nasally administered RSV-specific immune globulin (RSVIG) given prophylactically in a large volume (100 microL) reduced illness and RSV replication in lung after primary challenge. However, passive antibody treatment diminished the host antibody response to primary RSV infection. This resulted in greater susceptibility to reinfection and an alteration in the composition of the immune response after rechallenge. RSV infection of lung during primary infection was necessary for complete protection of lung from RSV rechallenge. Nasal infection alone during primary infection was not sufficient to protect against RSV rechallenge of lung, suggesting that the immune responses in the murine system are compartmentalized. The influence of compartmentalized immunity and modulation of immune responses will be important considerations as new approaches for topical immunoprophylaxis of RSV are developed.
在呼吸道合胞病毒（RSV）感染的小鼠模型中，研究了被动抗体对病毒复制、疾病和免疫的调节作用。在初次攻击前预防性大剂量（100微升）鼻腔给予RSV特异性免疫球蛋白（RSVIG）可减轻疾病并减少肺中RSV的复制。然而，被动抗体治疗减弱了宿主对初次RSV感染的抗体反应。这导致对再次感染的易感性增加，并在再次攻击后改变免疫反应的组成。初次感染期间肺部的RSV感染对于肺部免受RSV再次攻击的完全保护是必要的。仅初次感染期间的鼻腔感染不足以预防肺部的RSV再次攻击，这表明小鼠系统中的免疫反应是分区的。随着RSV局部免疫预防新方法的开发，分区免疫的影响和免疫反应的调节将是重要的考虑因素。
