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加拿大曼尼托巴省和瑞典耶姆特兰省社区居住的老年重度药物使用者的处方模式。

Prescribing patterns for elderly community-dwelling heavy medicinal drug users in Manitoba, Canada and Jämtland, Sweden.

作者信息

Sitar D S, Boëthius G, Bergman U, Mitenko P A

机构信息

Clinical Pharmacology Section, University of Manitoba, Winnipeg, Canada.

出版信息

J Clin Epidemiol. 1995 Jun;48(6):825-31. doi: 10.1016/0895-4356(94)00189-w.

Abstract

Patterns of drugs prescribed for elderly community-dwelling heavy medicinal drug users were determined from random samples of data bases and compared between Manitoba, Canada and Jämtland, Sweden for the year 1981. Qualitatively, there was 80% concordance between the 20 most frequently prescribed drugs in Manitoba and in Jämtland. Gender differences were rare, but there were notable quantitative differences for prescription of specific drugs between the two jurisdictions. Drugs to treat cardiovascular diseases were prominent in both groups with thiazides, triamterene and alpha-methyldopa more frequently prescribed for Manitoba patients, and furosemide, potassium supplements and digoxin more frequently prescribed for patients from Jämtland. The frequent prescribing of codeine in combination analgesics in Manitoba and phenothiazines in Jämtland appears to represent geographically disparate approaches to the use of these drugs. Overall, the concordance of prescribed drugs for elderly heavy medicinal drug users from these two jurisdictions appears to outweigh the differences. These results indicate that data from studies of heavy medicinal drug users, at least in the industrialized world, may be more widely applicable than to the geographical location from where they were obtained.

摘要

通过对数据库随机抽样,确定了居住在社区的老年重度药物使用者所开药物的模式,并对1981年加拿大曼尼托巴省和瑞典耶姆特兰省的数据进行了比较。定性来看,曼尼托巴省和耶姆特兰省最常开具的20种药物之间有80%的一致性。性别差异很少见,但两个司法管辖区在特定药物的处方上存在显著的数量差异。治疗心血管疾病的药物在两组中都很突出,噻嗪类、氨苯蝶啶和α-甲基多巴在曼尼托巴省患者中处方更频繁,而速尿、钾补充剂和地高辛在耶姆特兰省患者中处方更频繁。曼尼托巴省在复方镇痛药中频繁开具可待因,而耶姆特兰省则频繁开具吩噻嗪类药物,这似乎代表了这两种药物在地理上不同的使用方式。总体而言,这两个司法管辖区老年重度药物使用者的处方药一致性似乎超过了差异。这些结果表明,至少在工业化国家,对重度药物使用者的研究数据可能比获取数据的地理位置具有更广泛的适用性。

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