McLoughlin P, Linton R A, Band D M
Laboratory of Applied Physiology, United Medical, St. Thomas's Hospital, London, UK.
Respir Physiol. 1995 Mar;99(3):303-12. doi: 10.1016/0034-5687(94)00108-c.
Both increasing [K+]a and falling pHa stimulate ventilation through an action on the peripheral chemoreceptors. We have examined the effect on afferent carotid chemoreceptor discharge, of intravenous infusion of lactic acid alone, KCl alone, and both combined at constant PETCO2 in anaesthetized, artificially ventilated cats. Infusions of lactic acid alone and KCl alone caused similar increases in both the mean and amplitude of oscillation of chemoreceptor discharge. In the case of the lactic acid alone infusion the increase in the amplitude of oscillation could be accounted for by the resultant increase in carbon dioxide production. Simultaneous infusion of KCl and lactic acid caused an increase in the mean and amplitude of the discharge which was greater than either given alone, although the combined effect was less than additive. The alterations in mean and amplitude of oscillation of discharge during infusion of both agents together may be completely accounted for by a combined effect of increased carbon dioxide production and elevated [K+]a.
升高动脉血[K⁺]和降低动脉血pH都会通过作用于外周化学感受器来刺激通气。我们在麻醉、人工通气的猫身上进行了实验，维持呼气末二氧化碳分压（PETCO₂）恒定，静脉输注乳酸、氯化钾以及二者混合液，观察其对颈动脉化学感受器传入放电的影响。单独输注乳酸和单独输注氯化钾均可使化学感受器放电的平均频率和振荡幅度出现相似的增加。单独输注乳酸时，振荡幅度的增加可归因于二氧化碳生成量的相应增加。同时输注氯化钾和乳酸会使放电的平均频率和幅度增加，且大于单独输注任何一种物质时的增加幅度，不过联合效应小于两者单独作用之和。两种物质同时输注时放电振荡的平均频率和幅度变化，可能完全是由二氧化碳生成增加和动脉血[K⁺]升高的联合作用所致。
