Kakhnovskiĭ I M, Solomatin A S
Ter Arkh. 1995;67(3):34-8.
Inhalation corticosteroids (beclometasone dipropionate, budesonide, flunisolide) proved effective against bronchial asthma (BA) and safe as they induce no severe systemic side effects. Of these three drugs side effects arise most frequently in administration of beclometasone dipropionate, least frequently of flunisolide. These inhalation corticosteroids are indicated both in non-steroid-dependent and steroid-dependent BA to reduce the dose of oral steroids or, if possible, for their complete discontinuation. Flunisolide is the most potent and effective of all inhalation corticosteroids used in current practice.
吸入性皮质类固醇(二丙酸倍氯米松、布地奈德、氟尼缩松)已被证明对支气管哮喘(BA)有效且安全,因为它们不会引起严重的全身副作用。在这三种药物中,二丙酸倍氯米松给药时出现副作用的频率最高,氟尼缩松出现的频率最低。这些吸入性皮质类固醇适用于非类固醇依赖型和类固醇依赖型BA,以减少口服类固醇的剂量,或者在可能的情况下,完全停用口服类固醇。氟尼缩松是目前临床使用的所有吸入性皮质类固醇中效力最强、效果最好的。