Landyshev Iu S, Grigorenko A A, Marikhina N S, Molochnaia S V
Ter Arkh. 1995;67(3):43-7.
As shown by morphofunctional examinations of hypophyseal-adrenal system in 137 BA patients and post mortem examinations of adrenal cortex in 72 BA cases, most pronounced defects in glucocorticosteroid (GCS) biosynthesis and metabolism were recorded in patients on long-term GCS regiments (5-10 years and more). They displayed low levels of 11-OCS and 17-OCS, enhanced transcortin binding capacity, diminished adrenocortical reserves. Beclometasone propionate, endobronchial liposomes with hydrocortisone had no negative adrenal effects.
对137例支气管哮喘（BA）患者垂体 - 肾上腺系统的形态功能检查以及72例BA患者肾上腺皮质的尸检结果显示，长期使用糖皮质激素（GCS）治疗方案（5 - 10年及更长时间）的患者，糖皮质激素（GCS）生物合成和代谢存在最明显的缺陷。他们表现出11 - 氧皮质类固醇（11 - OCS）和17 - 氧皮质类固醇（17 - OCS）水平低、皮质素结合能力增强、肾上腺皮质储备减少。丙酸倍氯米松、含氢化可的松的支气管内脂质体对肾上腺无不良影响。
